{"id":13,"date":"2020-08-22T21:25:52","date_gmt":"2020-08-22T21:25:52","guid":{"rendered":"http:\/\/kleefstrasyndrome.com\/?page_id=13"},"modified":"2026-08-18T12:54:56","modified_gmt":"2026-08-18T10:54:56","slug":"kleefstra-syndrome","status":"publish","type":"page","link":"https:\/\/kleefstrasyndrome.com\/el\/kleefstra-syndrome\/","title":{"rendered":"\u03a4\u03bf \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra"},"content":{"rendered":"\n<div class=\"wp-block-group syndrome-page\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">\u03a4\u03bf <strong>\u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra \u03c4\u03cd\u03c0\u03bf\u03c5 1 (KLEFS1)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 <strong>EHMT1<\/strong>, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae 9q34.3 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 9. \u0395\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 \u03b1\u03c0\u03cc \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03c3\u03b5 \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf. \u0397 \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c0\u03b7\u03c1\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03bf\u03c4\u03bf\u03bd\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b9\u03b4\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03bf\u03b9 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03b9\u03bb\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1, \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03c6\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c5\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03b9 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03b9\u03bc\u03b1 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03bb\u03b7\u03c8\u03af\u03b1, \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03cd\u03c0\u03bd\u03bf\u03c5, \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03ba\u03bf\u03ae\u03c2 \u03ae \u03cc\u03c1\u03b1\u03c3\u03b7\u03c2, \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1, \u03b4\u03c5\u03c3\u03ba\u03bf\u03b9\u03bb\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1, \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c8\u03c5\u03c7\u03b9\u03ba\u03ae\u03c2 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2. <strong>\u039a\u03b1\u03bd\u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03bf, \u03cc\u03bc\u03c9\u03c2, \u03b4\u03b5\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b1 \u03c4\u03ad\u03bb\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 1990, \u03c4\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b5\u03af\u03c7\u03b1\u03bd \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c5\u03bb\u03b9\u03ba\u03bf\u03cd \u03c3\u03c4\u03bf \u03ac\u03ba\u03c1\u03bf \u03c4\u03bf\u03c5 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 9. \u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03b1\u03c5\u03c4\u03cc \u03b7 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03cc\u03c4\u03b1\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c9\u03c2 <strong>\u00ab9q subtelomeric deletion syndrome\u00bb<\/strong>, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c5\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03bc\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 9q.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf 2005, \u03b7 \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03c4\u03cc\u03bc\u03bf\u03c5 \u03bc\u03b5 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b4\u03b9\u03ac\u03c4\u03b1\u03be\u03b7 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03ad\u03ba\u03bf\u03c0\u03c4\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c4\u03bf <em>EHMT1<\/em> \u03c5\u03c0\u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03ae\u03c4\u03b1\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b1\u03c4\u03b1 \u03c4\u03bf \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae\u03c2. \u03a4\u03bf 2006, \u03b7 \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ce\u03bd \u03b1\u03c0\u03b5\u03c5\u03b8\u03b5\u03af\u03b1\u03c2 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf <em>EHMT1<\/em> \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03b9\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5. \u0388\u03c4\u03c3\u03b9 \u03ad\u03b3\u03b9\u03bd\u03b5 \u03c3\u03b1\u03c6\u03ad\u03c2 \u03cc\u03c4\u03b9 <strong>\u03b4\u03b5\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bb\u03b5\u03af\u03c0\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03ba\u03bf\u03bc\u03bc\u03ac\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 9 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 Kleefstra<\/strong>. \u03a3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03bf\u03b9 \u03bc\u03b9\u03c3\u03bf\u03af \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03b9 \u03bc\u03b5 KLEFS1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03bf \u03bc\u03b9\u03ba\u03c1\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03c4\u03bf <em>EHMT1<\/em>, \u03b5\u03bd\u03ce \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03bf\u03b9 \u03ac\u03bb\u03bb\u03bf\u03b9 \u03bc\u03b9\u03c3\u03bf\u03af \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03ae \u03ac\u03bb\u03bb\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c3\u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03ac\u03c6\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf. \u0388\u03bd\u03b1 \u03bc\u03b9\u03ba\u03c1\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b9\u03bf \u03c3\u03cd\u03bd\u03b8\u03b5\u03c4\u03b5\u03c2 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2.<\/p>\n\n\n\n<div id=\"quick-nav\" class=\"wp-block-group syndrome-quick-nav\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\"><strong>\u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03c0\u03bb\u03bf\u03ae\u03b3\u03b7\u03c3\u03b7<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"#ehmt1\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf EHMT1; <\/a><\/li>\n\n\n\n<li><a href=\"#charaktiristika\" data-type=\"internal\" data-id=\"#charaktiristika\">\u03a4\u03b1 \u03c0\u03b9\u03bf \u03ba\u03bf\u03b9\u03bd\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac <\/a><\/li>\n\n\n\n<li><a href=\"#diaforopoiisi\" data-type=\"internal\" data-id=\"#diaforopoiisi\">\u039c\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 \u03b1\u03c0\u03cc \u03ac\u03c4\u03bf\u03bc\u03bf \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf <\/a><\/li>\n\n\n\n<li><a href=\"#syxnotita\">\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 <\/a><\/li>\n\n\n\n<li><a href=\"#diagnosi\" data-type=\"internal\" data-id=\"#diagnosi\">\u0394\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 <\/a><\/li>\n\n\n\n<li><a href=\"#klironomikotita\" data-type=\"internal\" data-id=\"#klironomikotita\">\u039a\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 <\/a><\/li>\n\n\n\n<li><a href=\"#type2\" data-type=\"internal\" data-id=\"#type2\">Kleefstra syndrome type 2<\/a> <\/li>\n\n\n\n<li><a href=\"#ehmt2\" data-type=\"internal\" data-id=\"#ehmt2\">EHMT2 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 <\/a><\/li>\n\n\n\n<li><a href=\"#therapeia\" data-type=\"internal\" data-id=\"#therapeia\">\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 <\/a><\/li>\n\n\n\n<li><a href=\"#eniliki-zoi\" data-type=\"internal\" data-id=\"#therapeia\">\u0395\u03bd\u03ae\u03bb\u03b9\u03ba\u03b7 \u03b6\u03c9\u03ae \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b4\u03cc\u03ba\u03b9\u03bc\u03bf <\/a><\/li>\n\n\n\n<li><a href=\"#palia-simera\" data-type=\"internal\" data-id=\"#palia-simera\">\u03a0\u03b1\u03bb\u03b9\u03ac \u03ba\u03b1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<h3 id=\"ehmt1\" class=\"wp-block-heading\" style=\"font-size:22px\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf EHMT1;<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf <em>EHMT1<\/em> \u03b4\u03af\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03bc\u03b9\u03b1\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c9\u03c2 <strong>\u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03ae\u03c2<\/strong>. \u039c\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 EHMT2\/G9a \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03bc\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c7\u03c1\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd, \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03ac\u03bb\u03bb\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03c4\u03cc\u03bd\u03b7\u03c2 H3 \u03c3\u03c4\u03b7 \u03bb\u03c5\u03c3\u03af\u03bd\u03b7 9. \u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03b2\u03bf\u03b7\u03b8\u03ac \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03c5\u03bd <strong>\u03c0\u03bf\u03b9\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03ac, \u03c0\u03cc\u03c4\u03b5 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03b9\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03bf KLEFS1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 <strong>\u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03ac\u03c6\u03bf\u03c5 \u03c4\u03bf\u03c5 EHMT1<\/strong>. \u03a4\u03bf \u03ac\u03c4\u03bf\u03bc\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03b5\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03ad\u03bd\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03af\u03b3\u03c1\u03b1\u03c6\u03bf, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ae \u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac \u03b4\u03b5\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1. \u0391\u03c5\u03c4\u03cc \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 <strong>haploinsufficiency \u2013 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03ac\u03c6\u03bf\u03c5<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03c4\u03bf EHMT1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03ac\u03bb\u03bb\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7, \u03bf\u03b9 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b5\u03c2 \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03cc\u03c1\u03b3\u03b1\u03bd\u03bf. \u0391\u03c5\u03c4\u03cc \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03b5\u03be\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1\u03c4\u03af \u03c4\u03bf Kleefstra \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 <strong>\u03c0\u03bf\u03bb\u03c5\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf<\/strong>.<\/p>\n\n\n\n<div class=\"wp-block-group syndrome-features\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 id=\"charaktiristika\" class=\"wp-block-heading\">\u03a4\u03b1 \u03c0\u03b9\u03bf \u03ba\u03bf\u03b9\u03bd\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 Kleefstra \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03ac\u03c4\u03bf\u03bc\u03bf \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1\u03c2. \u039f\u03b9 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 2026 \u03ba\u03b1\u03b9 \u03c4\u03bf GeneReviews \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c9\u03c2 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd <strong>\u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03ae\/\u03ba\u03b1\u03b9 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c0\u03b7\u03c1\u03af\u03b1, \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c4\u03bf\u03bd\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b9\u03b4\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03c4\u03b9\u03c2 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03b9\u03bb\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1, \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03c6\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c5\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03b9 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03ce\u03c0\u03bf\u03c5<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u0391\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 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\u03b1\u03bd\u03b1\u03c0\u03b7\u03c1\u03af\u03b1. \u03a0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03ad\u03b4\u03b9\u03bd\u03b1\u03bd \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03ad\u03bc\u03c6\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2, \u03cc\u03bc\u03c9\u03c2 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b7\u03c0\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u03a5\u03c0\u03bf\u03c4\u03bf\u03bd\u03af\u03b1<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 <strong>\u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03c5\u03ca\u03ba\u03ae \u03c4\u03ac\u03c3\u03b7<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b7 \u03b2\u03c1\u03b5\u03c6\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03b4\u03c1\u03ae\u03c2 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c4\u03bf \u03ba\u03ac\u03b8\u03b9\u03c3\u03bc\u03b1, \u03c3\u03c4\u03b7\u03bd \u03cc\u03c1\u03b8\u03b9\u03b1 \u03c3\u03c4\u03ac\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03c0\u03ac\u03c4\u03b7\u03bc\u03b1.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u039a\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03b9\u03bb\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03b9\u03bb\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b3\u03bb\u03ce\u03c3\u03c3\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2. \u0397 \u03b5\u03ba\u03c6\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bf\u03bc\u03b9\u03bb\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af 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\u03c3\u03b5\u03b9\u03c1\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03be\u03b9\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 2026, \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 <strong>65% \u03c4\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03c4\u03c1\u03b9\u03ce\u03bd \u03b5\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bd\u03c9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2<\/strong>. \u03a3\u03c7\u03b5\u03b4\u03cc\u03bd \u03cc\u03bb\u03bf\u03b9 \u03cc\u03c3\u03bf\u03b9 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03c3\u03b1\u03bd \u03c0\u03c1\u03bf\u03c6\u03bf\u03c1\u03b9\u03ba\u03cc \u03bb\u03cc\u03b3\u03bf \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03b6\u03b1\u03bd \u03ba\u03ac\u03c0\u03bf\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03bf\u03bc\u03b9\u03bb\u03af\u03b1\u03c2.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u0391\u03c5\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03c6\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c5\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c3\u03c5\u03c7\u03bd\u03ac. \u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03c1\u03b5\u03bf\u03c4\u03c5\u03c0\u03af\u03b5\u03c2, \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae\u03c2, \u03ac\u03b3\u03c7\u03bf\u03c2, \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03ae \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c8\u03c5\u03c7\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2. \u039f\u03b9 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac\u03c2 \u03ae \u03c8\u03c5\u03c7\u03b9\u03ba\u03ae\u03c2 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 <strong>74%<\/strong> \u03c4\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03cd\u03c0\u03bd\u03bf\u03c5<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f \u03cd\u03c0\u03bd\u03bf\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1. \u03a0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 <strong>55%<\/strong> \u03c4\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03c3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 2026 \u03b5\u03af\u03c7\u03b1\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03cd\u03c0\u03bd\u03bf\u03c5, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ae \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03cd\u03c0\u03bd\u03bf\u03c5.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u0394\u03c5\u03c3\u03ba\u03bf\u03b9\u03bb\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b4\u03c5\u03c3\u03ba\u03bf\u03b9\u03bb\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 <strong>\u03c3\u03c4\u03bf\u03c5\u03c2 \u03bc\u03b9\u03c3\u03bf\u03cd\u03c2<\/strong> \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03bc\u03b5 KLEFS1 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ae\u03c0\u03b9\u03b1 \u03ad\u03c9\u03c2 \u03c0\u03bf\u03bb\u03cd \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae. \u03a3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03ba\u03bf\u03bc\u03bc\u03ac\u03c4\u03b9 \u03c4\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1\u03c2, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03c4\u03bf\u03bd \u03cd\u03c0\u03bd\u03bf, \u03c4\u03b7 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c5\u03b5\u03be\u03af\u03b1.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u03a0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03ba\u03bf\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03cc\u03c1\u03b1\u03c3\u03b7\u03c2<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03ba\u03bf\u03ae\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf <strong>37%<\/strong> \u03c4\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd. \u03a3\u03c5\u03c7\u03bd\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c1\u03b1\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03c4\u03c1\u03c9\u03c0\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bf \u03c3\u03c4\u03c1\u03b1\u03b2\u03b9\u03c3\u03bc\u03cc\u03c2, \u03b5\u03bd\u03ce \u03c0\u03bb\u03ad\u03bf\u03bd \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 (CVI).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u0395\u03c0\u03b9\u03bb\u03b7\u03c8\u03af\u03b1<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b5\u03c0\u03b9\u03bb\u03b7\u03c8\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ae \u03b1\u03bb\u03bb\u03ac <strong>\u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2<\/strong>. \u039f\u03b9 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03af\u03bd\u03bf\u03c5\u03bd \u03b1\u03c1\u03ba\u03b5\u03c4\u03ac \u03b5\u03c5\u03c1\u03cd \u03b5\u03cd\u03c1\u03bf\u03c2, \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 <strong>10%\u201344%<\/strong>, \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2 \u03ba\u03c1\u03af\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03c9\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac, \u03b5\u03c6\u03ae\u03b2\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2. \u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03b1\u03c5\u03c4\u03cc \u03bf\u03b9 \u03bd\u03ad\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b4\u03af\u03bd\u03bf\u03c5\u03bd \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03ad\u03bc\u03c6\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2, \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03b9 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03ce\u03c0\u03bf\u03c5<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03ad\u03bc\u03c0\u03b5\u03b9\u03c1\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03c3\u03c4\u03ae. \u0391\u03c5\u03c4\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b2\u03c1\u03b1\u03c7\u03c5\u03ba\u03b5\u03c6\u03b1\u03bb\u03af\u03b1, \u03c3\u03c5\u03bd\u03cc\u03c6\u03c1\u03c5\u03bf \u03ae \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03c6\u03c1\u03cd\u03b4\u03b9\u03b1, \u03c5\u03c0\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03ad\u03c3\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03ce\u03c0\u03bf\u03c5, \u03c0\u03c1\u03bf\u03ad\u03c7\u03bf\u03c5\u03c3\u03b1 \u03ba\u03ac\u03c4\u03c9 \u03b3\u03bd\u03ac\u03b8\u03bf \u03ba\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c7\u03ae\u03bc\u03b1 \u03c4\u03c9\u03bd \u03c7\u03b5\u03b9\u03bb\u03b9\u03ce\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, <strong>\u03b4\u03b5\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03cc\u03bb\u03b1 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0388\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c9\u03bc\u03b1\u03bb\u03af\u03b5\u03c2, \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c5\u03c1\u03bf\u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b3\u03b1\u03c3\u03c4\u03c1\u03bf\u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae \u03c0\u03b1\u03bb\u03b9\u03bd\u03b4\u03c1\u03cc\u03bc\u03b7\u03c3\u03b7, \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 \u03c3\u03af\u03c4\u03b9\u03c3\u03b7\u03c2, \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2, \u03bf\u03b4\u03bf\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c9\u03bc\u03b1\u03bb\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03c1\u03b8\u03bf\u03c0\u03b5\u03b4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03bb\u03b5\u03b9 \u03ba\u03b1\u03b9 <strong>\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 Kleefstra \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03ad\u03bd\u03b1 \u03c0\u03b1\u03b9\u03b4\u03af \u03b8\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03c3\u03b5\u03b9 \u03cc\u03bb\u03b1 \u03ae \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac<\/strong>.<\/p>\n\n\n\n<p class=\"is-style-info wp-block-paragraph\"><strong>\u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bd\u03b1 \u201c\u03c4\u03c5\u03c0\u03b9\u03ba\u03cc \u03c0\u03b1\u03b9\u03b4\u03af \u03bc\u03b5 Kleefstra\u201d.<\/strong> \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03b4\u03b5\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf\u03c5 \u03ac\u03bb\u03bb\u03bf\u03c5, \u03bf\u03cd\u03c4\u03b5 \u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c8\u03b5\u03b9 \u03bc\u03b5 \u03b1\u03ba\u03c1\u03af\u03b2\u03b5\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03c0\u03b1\u03b9\u03b4\u03b9\u03bf\u03cd.&nbsp;<\/p>\n<\/div><\/div>\n\n\n\n<h2 id=\"diaforopoiisi\" class=\"wp-block-heading\">\u039c\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 \u03b1\u03c0\u03cc \u03ac\u03c4\u03bf\u03bc\u03bf \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf KLEFS1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03bc\u03af\u03b1 \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03ae \u00ab\u03c4\u03c5\u03c0\u03b9\u03ba\u03ae\u00bb \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ae\u03c0\u03b9\u03b5\u03c2 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 \u03ad\u03c9\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03ae \u03b2\u03b1\u03b8\u03b9\u03ac \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c0\u03b7\u03c1\u03af\u03b1. \u0397 \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1, \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac, \u03c3\u03c4\u03b7\u03bd \u03b1\u03c5\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b5\u03c2. \u0391\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c1\u03ba\u03b5\u03c4\u03ac \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf <em>EHMT1<\/em>, \u03ba\u03b1\u03b9 \u03b3\u03b5\u03b9\u03c4\u03bf\u03bd\u03b9\u03ba\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03bc\u03ad\u03c3\u03bf \u03cc\u03c1\u03bf \u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1. \u0391\u03c5\u03c4\u03cc \u03cc\u03bc\u03c9\u03c2 <strong>\u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae \u03c0\u03c1\u03cc\u03b2\u03bb\u03b5\u03c8\u03b7 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c0\u03b1\u03b9\u03b4\u03af \u03bc\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 \u03ae \u03c4\u03bf \u03b5\u03af\u03b4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae\u03c2<\/strong>.<\/p>\n\n\n\n<h2 id=\"syxnotita\" class=\"wp-block-heading is-style-default\">\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03b3\u03c1\u03b1\u03c6\u03ae \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03c9\u03bd \u03bc\u03b5 KLEFS1 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03bf \u03bd\u03b1 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03b9\u03c3\u03c4\u03b5\u03af. \u03a4\u03bf GeneReviews \u03b5\u03ba\u03c4\u03b9\u03bc\u03ac \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 <strong>1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03b1\u03bd\u03ac 25.000\u201335.000<\/strong>, \u03b5\u03bd\u03ce \u03bf\u03b9 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 2026 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 <strong>1 \u03b1\u03bd\u03ac 36.000<\/strong>. \u0397 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b1\u03c1\u03ba\u03b5\u03c4\u03bf\u03af \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03b9 \u2014\u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c3\u03bf\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b7\u03c0\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1\u2014 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03b1\u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03c4\u03bf\u03b9. \u0391\u03c5\u03c4\u03cc \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03bd\u03c4\u03af\u03bb\u03b7\u03c8\u03b7 \u03cc\u03c4\u03b9 \u03c4\u03bf Kleefstra \u03ae\u03c4\u03b1\u03bd \u03ad\u03bd\u03b1 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bc\u03cc\u03bd\u03bf \u03ad\u03bd\u03b1\u03bd \u03c0\u03bf\u03bb\u03cd \u03bc\u03b9\u03ba\u03c1\u03cc \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03c9\u03bd \u03bc\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 id=\"diagnosi\" class=\"wp-block-heading\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b5\u03af\u03c7\u03b5 \u03c0\u03c1\u03c9\u03c4\u03bf\u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03b9\u03c3\u03c4\u03b5\u03af \u03c9\u03c2 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae, \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b2\u03b1\u03c3\u03b9\u03b6\u03cc\u03c4\u03b1\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03c9\u03c2 FISH, \u03ba\u03b1\u03c1\u03c5\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2, chromosomal microarray \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03bf\u03c5 <em>EHMT1<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 2026 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03c0\u03bb\u03ad\u03bf\u03bd \u03c9\u03c2 <strong>\u03c0\u03c1\u03ce\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf genome sequencing (GS)<\/strong> \u03ae, \u03cc\u03c4\u03b1\u03bd \u03b1\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf, <strong>exome sequencing (ES)<\/strong>, \u03ba\u03b1\u03c4\u03ac \u03c0\u03c1\u03bf\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c9\u03c2 trio \u2014\u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c0\u03b1\u03b9\u03b4\u03af \u03ba\u03b1\u03b9 \u03b4\u03cd\u03bf \u03b3\u03bf\u03bd\u03b5\u03af\u03c2\u2014 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ce\u03bd \u03c3\u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03ac\u03c6\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03b1\u03b4\u03b9\u03b1\u03c4\u03ac\u03be\u03b5\u03c9\u03bd. \u0391\u03bd \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b7\u03b3\u03b7\u03b8\u03b5\u03af chromosomal microarray.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03b5 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b7\u03b8\u03b5\u03af \u03c0\u03b9\u03bf \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03bf\u03c5 <em>EHMT1<\/em> \u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 <strong>\u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 \u2013 episignature<\/strong> \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5. \u039c\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b1\u03b2\u03ad\u03b2\u03b1\u03b9\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2 (<strong>VUS<\/strong>) \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n\n\n\n<h2 id=\"klironomikotita\" class=\"wp-block-heading\">\u039a\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b5\u03af\u03c4\u03b1\u03b9;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf KLEFS1 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af <strong>\u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03cc \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03ae \u03c4\u03c1\u03cc\u03c0\u03bf \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7\u03c2<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03b7 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03bf\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 <strong>de novo<\/strong>, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03bf \u03c0\u03b1\u03b9\u03b4\u03af.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c0\u03b1\u03bd\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ae \u03b3\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03cc\u03c2 \u03bc\u03c9\u03c3\u03b1\u03ca\u03ba\u03b9\u03c3\u03bc\u03cc\u03c2, \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b1\u03b4\u03b9\u03b1\u03c4\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b3\u03bf\u03bd\u03ad\u03b1 \u03ae \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7 \u03b7\u03c0\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ae\u03c2. \u0395\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2, \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b5\u03c0\u03b1\u03bd\u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 <strong>\u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03bf\u03cd\u03c4\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 50% \u03bf\u03cd\u03c4\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b7\u03b4\u03b5\u03bd\u03b9\u03ba\u03cc\u03c2<\/strong>\u00b7 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ac \u03b3\u03b9\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03ad\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c0\u03c1\u03bf\u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9, \u03cc\u03c0\u03bf\u03c5 \u03b5\u03c6\u03b1\u03c1\u03bc\u03cc\u03b6\u03b5\u03c4\u03b1\u03b9, \u03b7 \u03c0\u03c1\u03bf\u03b5\u03bc\u03c6\u03c5\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c3\u03c5\u03b6\u03b7\u03c4\u03b7\u03b8\u03bf\u03cd\u03bd \u03cc\u03c4\u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2.<\/p>\n\n\n\n<h2 id=\"type2\" class=\"wp-block-heading\">\u03a4\u03b9 \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03bf \u00abKleefstra syndrome type 2\u00bb;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c3\u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b7 \u03bf\u03c1\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 <strong>\u03ad\u03c7\u03b5\u03b9 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03bb\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b7\u03b3\u03ad\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c3\u03cd\u03b3\u03c7\u03c5\u03c3\u03b7<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0393\u03b9\u03b1 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ac \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1, \u03b7 \u03b2\u03ac\u03c3\u03b7 OMIM \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03c3\u03b5 \u03c4\u03bf\u03bd \u03cc\u03c1\u03bf <strong>\u00abKleefstra syndrome type 2\u00bb<\/strong> \u03b3\u03b9\u03b1 \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03bf <em>KMT2C<\/em>. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 98 \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03c4\u03bf 2024 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b7 KMT2C-\u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03ae \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc EHMT1<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 2026 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c1\u03b7\u03c4\u03ac \u03cc\u03c4\u03b9 \u03b7 \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1 \u00abKleefstra syndrome type 2\u00bb \u03b3\u03b9\u03b1 \u03c4\u03bf <em>KMT2C<\/em> \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03cd\u03b3\u03c7\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b9\u03c2 \u03c3\u03c5\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf <strong>KLEFS1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf EHMT1<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03b1\u03c5\u03c4\u03cc, \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03b9\u03c3\u03c4\u03bf\u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03bf \u03cc\u03c1\u03bf\u03c2 <strong>\u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra \/ KLEFS1<\/strong> \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 <em>EHMT1<\/em>.<\/p>\n\n\n\n<h2 id=\"ehmt2\" class=\"wp-block-heading\">\u039a\u03b1\u03b9 \u03c4\u03b9 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03bf EHMT2 \u03c4\u03bf 2026;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf\u03bd \u0399\u03bf\u03cd\u03bb\u03b9\u03bf \u03c4\u03bf\u03c5 2026 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03c4\u03bf <em>Nature Communications<\/em> \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03b3\u03c1\u03b1\u03c8\u03b5 <strong>\u03b5\u03c0\u03c4\u03ac \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 de novo \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03bf EHMT2<\/strong>. \u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1, \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03b6\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03c4\u03bf KLEFS1. \u039f\u03b9 \u03c3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2 \u03c0\u03c1\u03cc\u03c4\u03b5\u03b9\u03bd\u03b1\u03bd \u03c4\u03bf\u03bd \u03cc\u03c1\u03bf <strong>\u00abEHMT2-related Kleefstra syndrome\u00bb<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03cc\u03bc\u03c9\u03c2, \u03b7 \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b7 EHMT2-\u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03b5\u03b9 <strong>\u03b4\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03ae \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03c6\u03ae<\/strong>, \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ae \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03bf\u03bd\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03ac \u03bc\u03b5 \u03c4\u03bf KLEFS1 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03b1\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03ba\u03b1\u03b9 <strong>\u03b4\u03b5\u03bd \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 2026 \u03b3\u03b9\u03b1 \u03c4\u03bf KLEFS1<\/strong>, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c4\u03bf <em>EHMT1<\/em>. \u0398\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bf\u03c1\u03b9\u03c3\u03c4\u03b5\u03af \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03c4\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 EHMT2-\u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2.<\/p>\n\n\n\n<h2 id=\"therapeia\" class=\"wp-block-heading\">\u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03ae\u03bc\u03b5\u03c1\u03b1 <strong>\u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03bf EHMT1 \u03ae \u03bd\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf KLEFS1 \u03c9\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b9\u03c4\u03af\u03b1<\/strong>. \u0397 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03bc\u03ad\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03b3\u03ba\u03ce\u03bd: \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7, \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1, \u03cd\u03c0\u03bd\u03bf\u03c2, \u03b5\u03c0\u03b9\u03bb\u03b7\u03c8\u03af\u03b1, \u03c8\u03c5\u03c7\u03b9\u03ba\u03ae \u03c5\u03b3\u03b5\u03af\u03b1, \u03cc\u03c1\u03b1\u03c3\u03b7, \u03b1\u03ba\u03bf\u03ae, \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac, \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03c5\u03b3\u03b5\u03af\u03b1, \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1. \u039f\u03b9 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 2026 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac <strong>66 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2<\/strong> \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1 \u03b2\u03af\u03bf\u03c5 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03b1\u03c1\u03c7\u03af\u03c3\u03b5\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03ba\u03b9\u03bd\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c0\u03bb\u03ae \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c4\u03bf\u03bd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc. \u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03c4\u03bf 2026 \u03b1\u03bd\u03b1\u03ba\u03bf\u03b9\u03bd\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b1\u03ba\u03b1\u03b4\u03b7\u03bc\u03b1\u03ca\u03ba\u03cc \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 EHMT1 \u03bc\u03ad\u03c3\u03c9 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 RNA. \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b5\u03b3\u03b3\u03af\u03c3\u03b5\u03b9\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c3\u03b5 <strong>\u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/strong>.<\/p>\n\n\n\n<h2 id=\"eniliki-zoi\" class=\"wp-block-heading\">\u03a4\u03b9 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b7 \u03b6\u03c9\u03ae \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c3\u03b4\u03cc\u03ba\u03b9\u03bc\u03bf;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b3\u03bd\u03ce\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03bc\u03b5 KLEFS1 \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b3\u03bd\u03ce\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac. \u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03bf\u03b9 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b4\u03af\u03bd\u03bf\u03c5\u03bd \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03ad\u03bc\u03c6\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1 \u03b2\u03af\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03c5\u03c0\u03b7\u03c1\u03b5\u03c3\u03af\u03b5\u03c2 \u03b5\u03bd\u03b7\u03bb\u03af\u03ba\u03c9\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b4\u03bf\u03b8\u03b5\u03af \u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03bf\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c3\u03b4\u03cc\u03ba\u03b9\u03bc\u03bf \u03b6\u03c9\u03ae\u03c2. \u03a0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c8\u03b5\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03b1\u03c0\u03cc \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2, \u03b5\u03b9\u03c3\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1 \u03b3\u03b5\u03bd\u03b9\u03ba\u03b5\u03cd\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c3\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03bc\u03b5 KLEFS1.<\/p>\n\n\n\n<h2 id=\"palia-simera\" class=\"wp-block-heading\">\u03a4\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03cc\u03c3\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03b1\u03bc\u03b5 \u03c0\u03b1\u03bb\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c3\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2:<\/p>\n\n\n\n<div class=\"wp-block-columns past-present-row is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column past-card is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u03a0\u03b1\u03bb\u03b9\u03ac \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u00ab\u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 9q34\u00bb.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03b7 \u03c0\u03bf\u03bb\u03cd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03ae \u03b1\u03c0\u03bf\u03cd\u03c3\u03b1 \u03bf\u03bc\u03b9\u03bb\u03af\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03b1\u03b6\u03cc\u03c4\u03b1\u03bd \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c9\u03c2 \u03ba\u03b1\u03b8\u03bf\u03bb\u03b9\u03ba\u03cc \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc.<\/li>\n\n\n\n<li>\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03bd\u03cc\u03c4\u03b1\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7, \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03bb\u03b7\u03c8\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03bd\u03c9\u03bc\u03b1\u03bb\u03af\u03b5\u03c2.<\/li>\n\n\n\n<li>\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03c1\u03b9\u03b6\u03cc\u03c4\u03b1\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03b5 microarray, FISH \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/li>\n\n\n\n<li>\u03c4\u03bf <em>KMT2C<\/em> \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03cc\u03c4\u03b1\u03bd \u03c9\u03c2 \u00abKleefstra syndrome type 2\u00bb.<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column present-card is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u03a3\u03ae\u03bc\u03b5\u03c1\u03b1&#8230;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"old-label\">\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03c4\u03bf KLEFS1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03cd\u03c0\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 <em>EHMT1<\/em>.<\/li>\n\n\n\n<li class=\"now-label\">\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03b9\u03b1\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03bf\u03af \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03b9 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c3\u03c3\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03c6\u03bf\u03c1\u03b9\u03ba\u03cc \u03bb\u03cc\u03b3\u03bf, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03bf\u03bc\u03b9\u03bb\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03bb\u03ce\u03c3\u03c3\u03b1\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03cd \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2.<\/li>\n\n\n\n<li class=\"now-label\">\u03bf \u03cd\u03c0\u03bd\u03bf\u03c2, \u03b7 \u03c8\u03c5\u03c7\u03b9\u03ba\u03ae \u03c5\u03b3\u03b5\u03af\u03b1, \u03c4\u03bf regression, \u03b7 \u03b4\u03c5\u03c3\u03ba\u03bf\u03b9\u03bb\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1, \u03b7 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b7 \u03b6\u03c9\u03ae \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1\u03c2.<\/li>\n\n\n\n<li class=\"now-label\">genome \u03ae exome sequencing, \u03ba\u03b1\u03c4\u03ac \u03c0\u03c1\u03bf\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c9\u03c2 trio \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ce\u03bd, \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c4\u03b5\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7.<\/li>\n\n\n\n<li class=\"old-label\">\u03c4\u03b1 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03ae KMT2C-\u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b8\u03b1 \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b5\u03bb\u03af\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03c4\u03cc\u03c3\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf, \u03cc\u03c0\u03bf\u03c5 \u03c0\u03bf\u03bb\u03bb\u03ac \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b2\u03b1\u03c3\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03bd \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03c3\u03b5\u03b9\u03c1\u03ad\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd. \u0391\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 2026 \u03b5\u03c0\u03b9\u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03af\u03c9\u03c3\u03b7\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03cd \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b5\u03c7\u03cc\u03bd\u03c4\u03c9\u03bd.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"is-style-info wp-block-paragraph\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03af\u03bd\u03b9\u03c3\u03b7: \u0397 \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b1 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af <strong>\u03b5\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03ae \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03b4\u03bf\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b3\u03bd\u03ce\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra \u03c4\u03cd\u03c0\u03bf\u03c5 1 (KLEFS1\/EHMT1)<\/strong>. \u0394\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03bc\u03b7 \u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03b9\u03b5\u03b8\u03bd\u03ce\u03bd \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03c9\u03bd \u03bf\u03b4\u03b7\u03b3\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ae \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b5\u03c2 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 13 \u0391\u03c5\u03b3\u03bf\u03cd\u03c3\u03c4\u03bf\u03c5 2026<\/strong><\/p>\n\n\n\n<div class=\"wp-block-group syndrome-sources\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">\u0392\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b7\u03b3\u03ad\u03c2<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Bouman A. et al. <strong>International clinical evidence-based guideline for Kleefstra syndrome<\/strong>. <em>Genetics in Medicine<\/em>, 2026.<\/li>\n\n\n\n<li>Kleefstra T, de Leeuw N. <strong>Kleefstra Syndrome \u2013 GeneReviews\u00ae<\/strong>. National Center for Biotechnology Information.<\/li>\n\n\n\n<li>Kleefstra T. et al. <strong>Disruption of the gene Euchromatin Histone Methyl Transferase 1 (Eu-HMTase1) is associated with the 9q34 subtelomeric deletion syndrome<\/strong>, 2005.<\/li>\n\n\n\n<li>Kleefstra T. et al. <strong>Loss-of-function mutations in EHMT1 cause the 9q34 subtelomeric deletion syndrome<\/strong>, 2006.<\/li>\n\n\n\n<li>Rots D. et al. <strong>Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes<\/strong>. <em>American Journal of Human Genetics<\/em>, 2024.<\/li>\n\n\n\n<li>Hn\u00edzda A. et al. <strong>De novo EHMT2 variants cause an autosomal dominant EHMT2-related Kleefstra syndrome via loss of G9a methyltransferase activity<\/strong>. <em>Nature Communications<\/em>, 2026.<\/li>\n<\/ul>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra \u03c4\u03cd\u03c0\u03bf\u03c5 1 (KLEFS1) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"class_list":["post-13","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - 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