{"id":189,"date":"2018-09-06T11:56:30","date_gmt":"2018-09-06T09:56:30","guid":{"rendered":"http:\/\/kleefstrasyndrome.com\/?p=189"},"modified":"2026-08-21T07:11:30","modified_gmt":"2026-08-21T05:11:30","slug":"pulmonary-hypertension-in-kleefstra-syndrome","status":"publish","type":"post","link":"https:\/\/kleefstrasyndrome.com\/el\/pulmonary-hypertension-in-kleefstra-syndrome\/","title":{"rendered":"\u03a0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">\u03a3\u03b5 \u03bc\u03af\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03bf\u03b9 Volkan Okur \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c4\u03b5\u03c2 \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b1\u03bd \u03c3\u03c4\u03bf <em>American Journal of Medical Genetics Part A<\/em> \u03bc\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03c1\u03b9\u03ce\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03bc\u03b5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae 9q34.3, \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7. \u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03bf\u03b9 \u03c3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2 \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b1\u03bd \u03c0\u03ad\u03bd\u03c4\u03b5 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03c7\u03b1\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03c3\u03c4\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1, \u03b4\u03b9\u03b5\u03c1\u03b5\u03c5\u03bd\u03ce\u03bd\u03c4\u03b1\u03c2 \u03bc\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 <a href=\"http:\/\/www.hellenicpulmonaryhypertension.gr\/plerophories-gia-te-noso\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7<\/a> \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03af\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03b3\u03c7\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7. \u0397 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2, \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03ae \u03bd\u03b1 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03c5\u03bd\u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2, \u03bf\u03b9 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03cc\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2. \u039f\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03b1\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bf\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03c5\u03b8\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03b5\u03c2 \u03b1\u03b9\u03c4\u03af\u03b5\u03c2. \u0397 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Down \u03c3\u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03bf\u03b9 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1, \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 3 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 9q34.3 \u03bc\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7.<\/p>\n\n\n\n<div class=\"wp-block-group ph-case\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\"><strong>\u03a0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 1 \u2013 \u0391\u03b3\u03cc\u03c1\u03b9 18 \u03bc\u03b7\u03bd\u03ce\u03bd<\/strong>&nbsp;<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f&nbsp;<strong>\u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 1<\/strong>&nbsp;\u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03b3\u03cc\u03c1\u03b9 18 \u03bc\u03b7\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b3\u03b5\u03bd\u03bd\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c4\u03bf\u03ba\u03b5\u03c4\u03cc \u03c3\u03c4\u03bf \u03c4\u03ad\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2. \u0397 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 9q34.3 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra \u03ad\u03b3\u03b9\u03bd\u03b5 \u03c0\u03c1\u03bf\u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c3\u03c5\u03c3\u03c4\u03bf\u03b9\u03c7\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 3,45 Mb. \u039f \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 \u03c3\u03c4\u03bf \u03c0\u03c1\u03bf\u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1. \u03a4\u03bf \u03c5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b3\u03ad\u03bd\u03bd\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03ad\u03bb\u03bb\u03b5\u03b9\u03bc\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c3\u03bf\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03bf\u03cd \u03b4\u03b9\u03b1\u03c6\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 (Ventricular Septal Defect) \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03c4\u03cc\u03be\u03bf \u03bc\u03b5 \u03c3\u03c4\u03ad\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b9\u03c3\u03b8\u03bc\u03bf\u03cd \u03b1\u03bf\u03c1\u03c4\u03ae\u03c2 (Coarctation of the Aorta). \u0395\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1, \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 1 \u03b5\u03af\u03c7\u03b5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03b5\u03c6\u03b1\u03bb\u03af\u03b1, \u03c5\u03c0\u03bf\u03c4\u03bf\u03bd\u03af\u03b1, \u03b4\u03c5\u03c3\u03bc\u03bf\u03c1\u03c6\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac, \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd, \u03b1\u03c0\u03bf\u03c6\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bd\u03b9\u03ba\u03ae \u03ac\u03c0\u03bd\u03bf\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7. \u03a0\u03b1\u03c1\u03ac \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03b5\u03af\u03c7\u03b5 \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd, \u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1. \u03a0\u03c1\u03bf\u03c4\u03ac\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03ce\u03b8\u03b7\u03ba\u03b5. \u039f \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 1 \u03c5\u03c0\u03bf\u03b2\u03bb\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b5\u03af\u03bf \u03cc\u03c4\u03b1\u03bd \u03ae\u03c4\u03b1\u03bd 1 \u03bc\u03b7\u03bd\u03cc\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03bc\u03b5\u03c3\u03bf\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03cc \u03ad\u03bb\u03bb\u03b5\u03b9\u03bc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae \u03c4\u03bf\u03c5 \u03c4\u03cc\u03be\u03bf\u03c5. \u039c\u03b5\u03c4\u03ac \u03c4\u03bf \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b5\u03af\u03bf \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03bc\u03b7\u03c4\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bf\u03c1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03ad\u03bd\u03c9\u03c3\u03b7. \u03a3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03c4\u03c9\u03bd 9 \u03bc\u03b7\u03bd\u03ce\u03bd \u03b4\u03b9\u03b1\u03b3\u03bd\u03ce\u03c3\u03c4\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03b4\u03b5\u03be\u03b9\u03cc \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03cc \u03ba\u03b1\u03b8\u03b5\u03c4\u03b7\u03c1\u03b9\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1. \u0397 \u03c0\u03af\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03b1\u03c2 \u03ae\u03c4\u03b1\u03bd 53\/20 \u03bc\u03b5 mPAP 35 mmHg \u03ba\u03b1\u03b9 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 70\/45, \u03c0\u03bf\u03c5 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03bc\u03b9\u03c3\u03ad\u03c2 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b9\u03ad\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b5\u03be\u03b9\u03ac\u03c2 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac\u03c2. \u0397 \u03c0\u03af\u03b5\u03c3\u03b7 \u03b5\u03bd\u03c3\u03c6\u03ae\u03bd\u03c9\u03c3\u03b7\u03c2 (PAWP) \u03ae\u03c4\u03b1\u03bd 7 mmHg \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 (PVRi) \u03ae\u03c4\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03c4\u03b1 8,5 WU \u00d7 m2, \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 7,2 WU\u00b7m\u00b2 \u03bc\u03b5 \u03bf\u03be\u03b5\u03af\u03b1 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b4\u03b9\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bf \u03c4\u03cd\u03c0\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03ac\u03c2 \u03c4\u03bf\u03c5 \u03b4\u03b5 \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03c3\u03b1\u03bd \u03c4\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1. \u039e\u03b5\u03ba\u03af\u03bd\u03b7\u03c3\u03b5 \u03b1\u03b3\u03c9\u03b3\u03ae \u03bc\u03b5 \u03c3\u03b9\u03bb\u03b4\u03b5\u03bd\u03b1\u03c6\u03af\u03bb\u03b7 (sildenafil) \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd \u03bc\u03b5\u03c1\u03b9\u03ba\u03ce\u03c2. \u03a3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03c4\u03c9\u03bd 10 \u03bc\u03b7\u03bd\u03ce\u03bd \u03ad\u03c6\u03c5\u03b3\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b6\u03c9\u03ae \u03bb\u03cc\u03b3\u03c9 \u03ba\u03c5\u03ac\u03bd\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03c1\u03b1\u03b4\u03c5\u03ba\u03b1\u03c1\u03b4\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf \u03c3\u03c0\u03af\u03c4\u03b9, \u03cc\u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b4\u03b5 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group ph-case\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">\u03a0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 2 \u2013 \u039a\u03bf\u03c1\u03af\u03c4\u03c3\u03b9 7 \u03bc\u03b7\u03bd\u03ce\u03bd<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397&nbsp;<strong>\u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 2<\/strong>&nbsp;\u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03ba\u03bf\u03c1\u03af\u03c4\u03c3\u03b9 7 \u03bc\u03b7\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b3\u03b5\u03bd\u03bd\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c4\u03bf\u03ba\u03b5\u03c4\u03cc \u03c3\u03c4\u03bf \u03c4\u03ad\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2. \u039a\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b1 \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bd\u03b5\u03bf\u03b3\u03bd\u03ce\u03bd (NICU), \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03bf\u03b9\u03c7\u03c4\u03cc \u03b2\u03bf\u03c4\u03ac\u03bb\u03b9\u03bf \u03c0\u03cc\u03c1\u03bf (Patent Ductus Arteriosus), \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03bc\u03b5\u03c3\u03bf\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03cc \u03ad\u03bb\u03bb\u03b5\u03b9\u03bc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c3\u03bf\u03ba\u03bf\u03bb\u03c0\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1 (Atrial Septal Defect) \u03ba\u03b1\u03b9 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7. \u03a0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7, \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03b5\u03c6\u03b1\u03bb\u03af\u03b1 \u03ba\u03b1\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03c5\u03c0\u03bf\u03c4\u03bf\u03bd\u03af\u03b1. \u03a3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03c4\u03c9\u03bd 3 \u03bc\u03b7\u03bd\u03ce\u03bd \u03c5\u03c0\u03bf\u03b2\u03bb\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03cc \u03ba\u03b1\u03b8\u03b5\u03c4\u03b7\u03c1\u03b9\u03b1\u03c3\u03bc\u03cc, \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b5 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c0\u03af\u03b5\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03b1\u03c2 52\/20 \u03bc\u03b5 mPAP 37 mmHg. \u0397 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ae\u03c4\u03b1\u03bd 69\/32, PCWP 8 mmHg \u03ba\u03b1\u03b9 PVRi 3 WU \u00d7 m2 \u03bc\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c3\u03b5 1,9 WU \u00d7 m2 \u03c3\u03b5 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b4\u03b9\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd. \u039f\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ad\u03c2 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03bd\u03c9\u03bc\u03b1\u03bb\u03af\u03b5\u03c2 \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b1\u03bd \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03c9\u03bd \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c3\u03c5\u03c3\u03c4\u03bf\u03b9\u03c7\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03bc\u03b5\u03b3\u03ad\u03b8\u03bf\u03c5\u03c2 2,9 Mb \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 9q34.3, \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra. \u03a3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 5 \u03bc\u03b7\u03bd\u03ce\u03bd \u03c5\u03c0\u03bf\u03b2\u03bb\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2. \u039c\u03b5\u03c4\u03b5\u03b3\u03c7\u03b5\u03b9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac, \u03be\u03b5\u03ba\u03af\u03bd\u03b7\u03c3\u03b5 \u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \u03bc\u03b5 \u03c3\u03b9\u03bb\u03b4\u03b5\u03bd\u03b1\u03c6\u03af\u03bb\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7. \u039a\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7, \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group ph-case\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">\u03a0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 3 \u2013 \u039a\u03bf\u03c1\u03af\u03c4\u03c3\u03b9 3 \u03b5\u03c4\u03ce\u03bd<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397&nbsp;<strong>\u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 3<\/strong>&nbsp;\u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03ba\u03bf\u03c1\u03af\u03c4\u03c3\u03b9 3 \u03b5\u03c4\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b3\u03b5\u03bd\u03bd\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03bf \u03c4\u03ad\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03b9\u03c3\u03b1\u03c1\u03b9\u03ba\u03ae \u03c4\u03bf\u03bc\u03ae. \u0397 \u03ba\u03b1\u03b9\u03c3\u03b1\u03c1\u03b9\u03ba\u03ae \u03c4\u03bf\u03bc\u03ae \u03b5\u03c0\u03b9\u03bb\u03ad\u03c7\u03b8\u03b7\u03ba\u03b5 \u03bb\u03cc\u03b3\u03c9 \u03c0\u03c1\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03bc\u03c6\u03ac\u03bb\u03b9\u03bf\u03c5 \u03bb\u03ce\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03bf\u03cd \u03bc\u03b5 \u03b5\u03bd\u03b4\u03bf\u03bc\u03ae\u03c4\u03c1\u03b9\u03b1 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 (Intrauterine Growth Restriction), \u03ba\u03cd\u03c3\u03c4\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03b9\u03c3\u03c4\u03b5\u03c1\u03ae \u03ba\u03bf\u03b9\u03bb\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5 (2.1 \u00d7 1 cm) \u03ba\u03b1\u03b9 \u03ba\u03cd\u03c3\u03c4\u03b7 \u03c3\u03c4\u03b7 \u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ba\u03bf\u03b9\u03bb\u03cc\u03c4\u03b7\u03c4\u03b1. \u03a4\u03bf \u03b7\u03c7\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 \u03c3\u03c4\u03b7\u03bd 3\u03b7 \u03b7\u03bc\u03ad\u03c1\u03b1 \u03b6\u03c9\u03ae\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03bc\u03b5\u03c3\u03bf\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03cc \u03ad\u03bb\u03bb\u03b5\u03b9\u03bc\u03bc\u03b1, \u03bc\u03b9\u03ba\u03c1\u03ae \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03b5\u03cd\u03bf\u03c5\u03c3\u03b1 \u03bc\u03b5\u03c3\u03bf\u03ba\u03bf\u03bb\u03c0\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc \u03c0\u03c1\u03bf\u03c2 \u03bc\u03ad\u03c4\u03c1\u03b9\u03bf \u03b1\u03bd\u03bf\u03b9\u03c7\u03c4\u03cc \u03b2\u03bf\u03c4\u03ac\u03bb\u03b9\u03bf \u03c0\u03cc\u03c1\u03bf. \u03a3\u03c4\u03b7 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\u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03c9\u03bd.<\/p>\n\n\n\n<div class=\"wp-block-group study-conclusion\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">\u03a4\u03b9 \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03bd\u03b1\u03bd \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b1\u03bd, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae 9q34.3, \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7\u03c2 \u03bc\u03b9\u03b1\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae\u03c2 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7\u03c2. \u0394\u03b9\u03b1\u03c4\u03c5\u03c0\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03cc\u03c4\u03b9 \u03ad\u03bd\u03b1 \u03ae \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae\u03c2 \u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03c9\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03b1\u03bd \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b1\u03c5\u03c4\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bb\u03bf\u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 <strong>EHMT1<\/strong> \u03ae \u03bc\u03b5 \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf \u03ac\u03bb\u03bb\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae 9q34.3.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group study-source\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">\u03a0\u03b7\u03b3\u03ae<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Okur V, Nees S, Chung WK, Krishnan U.<\/strong> <em>Pulmonary hypertension in patients with 9q34.3 microdeletion-associated Kleefstra syndrome.<\/em> <strong>American Journal of Medical Genetics Part A.<\/strong> 2018;176(8):1773\u20131777. doi:10.1002\/ajmg.a.38852.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br>\u038c\u03bb\u03bf \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf \u03c3\u03c4\u03b1 \u03b1\u03b3\u03b3\u03bb\u03b9\u03ba\u03ac \u03b8\u03b1 \u03c4\u03bf \u03b2\u03c1\u03b5\u03af\u03c4\u03b5&nbsp;<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/ajmg.a.38852\">\u03b5\u03b4\u03ce<\/a><\/p>\n<\/div><\/div>\n\n\n\n<p class=\"is-style-warning wp-block-paragraph\"><strong>\u03a3\u03b7\u03bc\u03b5\u03af\u03c9\u03c3\u03b7:<\/strong> \u03a4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03c4\u03b9\u03ba\u03ae \u03c3\u03cd\u03bd\u03bf\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae \u03ae \u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2. \u0393\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03bf\u03c0\u03bf\u03b9\u03bf\u03c5\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03ae \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u03a3\u03b5 \u03bc\u03af\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03bf\u03b9 Volkan Okur \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c4\u03b5\u03c2 \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b1\u03bd \u03c3\u03c4\u03bf American Journal of Medical&#8230;<\/p>\n","protected":false},"author":1,"featured_media":2483,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"aside","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[9],"tags":[19,13,20,18],"class_list":["post-189","post","type-post","status-publish","format-aside","has-post-thumbnail","hentry","category-research","tag-hypertation","tag-kleefstra","tag-patients","tag-ulmonary","post_format-post-format-aside"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u03a0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra - \u03a4\u03bf \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/kleefstrasyndrome.com\/el\/pulmonary-hypertension-in-kleefstra-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u03a0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra - \u03a4\u03bf \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra\" \/>\n<meta property=\"og:description\" content=\"\u03a3\u03b5 \u03bc\u03af\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03bf\u03b9 Volkan Okur \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c4\u03b5\u03c2 \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b1\u03bd \u03c3\u03c4\u03bf American Journal of Medical...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/kleefstrasyndrome.com\/el\/pulmonary-hypertension-in-kleefstra-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"\u03a4\u03bf \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/kleefstrasyndromegr\" \/>\n<meta property=\"article:published_time\" content=\"2018-09-06T09:56:30+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-21T05:11:30+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/kleefstrasyndrome.com\/wp-content\/uploads\/2026\/08\/research_18.jpg\" \/>\n\t<meta property=\"og:image:width\" 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