{"id":2220,"date":"2024-09-12T22:59:53","date_gmt":"2024-09-12T20:59:53","guid":{"rendered":"https:\/\/kleefstrasyndrome.com\/?p=2220"},"modified":"2026-08-20T16:42:43","modified_gmt":"2026-08-20T14:42:43","slug":"ehmt1-variants-kleefstra-spectrum-2024","status":"publish","type":"post","link":"https:\/\/kleefstrasyndrome.com\/el\/ehmt1-variants-kleefstra-spectrum-2024\/","title":{"rendered":"\u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u2019 \u03cc\u03c3\u03bf \u03c0\u03b9\u03c3\u03c4\u03b5\u03cd\u03b1\u03bc\u03b5: \u03c4\u03b9 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03b7 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03bf\u03c5 EHMT1 \u03c3\u03b5 209 \u03ac\u03c4\u03bf\u03bc\u03b1"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">\u0393\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03ac \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1, \u03b7 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 Kleefstra \u03b2\u03b1\u03c3\u03b9\u03b6\u03cc\u03c4\u03b1\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1: \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7, \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03ad\u03c9\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c0\u03b7\u03c1\u03af\u03b1, \u03c5\u03c0\u03bf\u03c4\u03bf\u03bd\u03af\u03b1, \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03b9\u03bb\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03bc\u03b1\u03c4\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039a\u03b1\u03b8\u03ce\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b5\u03be\u03b5\u03bb\u03af\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7 \u03b5\u03be\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03bb\u03bf\u03ad\u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2, \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03bf\u03c5 <strong>EHMT1<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03bc\u03bf\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u00ab\u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae\u00bb \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf 2024, \u03bc\u03b9\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b4\u03b9\u03b5\u03b8\u03bd\u03ae\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03b5 \u03b5\u03c0\u03b9\u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03c4\u03bf\u03bd <strong>Dmitrijs Rots<\/strong>, \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03b7\u03c2 <strong>Tjitske Kleefstra<\/strong> \u03ba\u03b1\u03b9 \u03b4\u03b5\u03ba\u03ac\u03b4\u03c9\u03bd \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b1\u03c0\u03cc \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03c7\u03ce\u03c1\u03b5\u03c2, \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b5 \u03c3\u03c4\u03bf <em>American Journal of Human Genetics<\/em> \u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf KLEFS1. \u039f\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b1\u03bd <strong>209 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c3\u03c4\u03bf EHMT1<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03cd\u03b1\u03c3\u03b1\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1, \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7, \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA. \u039c\u03b5\u03c4\u03ac \u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7, \u03bf\u03b9 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 <strong>191 \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd<\/strong> \u03c4\u03b1\u03be\u03b9\u03bd\u03bf\u03bc\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03ae \u03b5\u03c0\u03b1\u03bd\u03b1\u03c4\u03b1\u03be\u03b9\u03bd\u03bf\u03bc\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03b5\u03c2 \u03ae \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03b5\u03c2, \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ac KLEFS1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1. \u0394\u03b5\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae \u03bd\u03ad\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd, \u03b1\u03bb\u03bb\u03ac \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03b7\u03b8\u03b5\u03af \u03ad\u03bd\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c0\u03b9\u03bf \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0393\u03b9\u03b1\u03c4\u03af \u03b4\u03cd\u03bf \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03b9 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03cc\u03c3\u03bf \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1;<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u0391\u03c0\u03cc \u03c4\u03bf \u00ab\u03c0\u03ce\u03c2 \u03bc\u03bf\u03b9\u03ac\u03b6\u03b5\u03b9 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf\u00bb \u03c3\u03c4\u03bf \u00ab\u03c4\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae\u00bb<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ac, \u03c0\u03bf\u03bb\u03bb\u03ac \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03bd \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03be\u03b5\u03ba\u03b9\u03bd\u03bf\u03cd\u03c3\u03b5 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf: \u03bf\u03b9 \u03b3\u03b9\u03b1\u03c4\u03c1\u03bf\u03af \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03ad\u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b1\u03bd\u03b1\u03b6\u03b7\u03c4\u03bf\u03cd\u03c3\u03b1\u03bd \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b9\u03c4\u03af\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03bb\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03c1\u03bf\u03c6\u03bf. \u0397 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03b9 \u03c0\u03c1\u03ce\u03c4\u03b1 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c0\u03b1\u03b8\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03b1\u03bd \u03b1\u03c5\u03c4\u03ae \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03bd\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03ce\u03bd \u03c4\u03b7\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03c4\u03bf Kleefstra. \u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03c9\u03bd Rots \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c4\u03ce\u03bd \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03c4\u03bf KLEFS1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03c0\u03bf\u03bb\u03cd \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf \u03c6\u03ac\u03c3\u03bc\u03b1 \u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ce\u03bd \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd<\/strong> \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03b3\u03c1\u03b1\u03c6\u03b1\u03bd \u03bf\u03b9 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c3\u03b5\u03b9\u03c1\u03ad\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd. \u03a3\u03c4\u03b7 \u03bd\u03ad\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c5\u03c0\u03ae\u03c1\u03c7\u03b1\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 <strong>\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/strong>, \u03ba\u03ac\u03c4\u03b9 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b4\u03b5\u03bd \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03bd \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c4\u03b7\u03c2 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae\u03c2 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03ac\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c0\u03b1\u03cd\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5 KLEFS1. \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03cc\u03c4\u03b9 <strong>\u03c4\u03bf \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b4\u03b5\u03bd \u03bc\u03b1\u03c2 \u03bb\u03ad\u03b5\u03b9 \u03c0\u03cc\u03c3\u03bf \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u03a4\u03bf EHMT1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03bc\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0393\u03b9\u03b1 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1\u03c2, \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03bf\u03cd\u03bc\u03b5 \u03bb\u03af\u03b3\u03bf \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf <strong>EHMT1<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd. \u03a3\u03b5 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5 \u03c4\u03bf EHMT2, \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03ac\u03bb\u03bb\u03c9\u03bd \u03c3\u03c4\u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03c4\u03cc\u03bd\u03b7\u03c2 H3 \u03c3\u03c4\u03b7 \u03bb\u03c5\u03c3\u03af\u03bd\u03b7 9 \u2014 \u03ad\u03bd\u03b1\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03bf\u03b9\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03ae \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03bd\u03b5\u03c1\u03b3\u03ac.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03cc\u03bc\u03c9\u03c2 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2. \u0394\u03cd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03b7 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae ANKR (ankyrin repeat domain)<\/strong> \u03ba\u03b1\u03b9<br><strong>\u03b7 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae SET<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b1\u03c0\u03bb\u03bf\u03c5\u03c3\u03c4\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf, \u03b7 ANKR \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u00ab\u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u00bb \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03b7\u03bc\u03b1\u03b4\u03b9\u03ce\u03bd \u2014 \u03b3\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03bf\u03b9 \u03c3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2 \u03bc\u03b9\u03bb\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1 <strong>reader function<\/strong> \u2014 \u03b5\u03bd\u03ce \u03b7 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae SET \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03b8\u03c5\u03bb\u03bf\u03c4\u03c1\u03b1\u03bd\u03c3\u03c6\u03b5\u03c1\u03ac\u03c3\u03b7\u03c2, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c9\u03c2 <strong>writer<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03ae\u03c4\u03b1\u03bd \u03cc\u03c4\u03b9 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c0\u03c9\u03c2 <strong>\u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03cc\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03bf\u03c5 EHMT1 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u0397 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae ANKR \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf KLEFS1<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c3\u03b1\u03bd \u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ac \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bb\u03bb\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd missense \u03ba\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ce\u03bd in-frame \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ce\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u038c\u03c4\u03b1\u03bd \u03bc\u03b9\u03b1 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b4\u03b9\u03b1\u03c4\u03ac\u03c1\u03b1\u03c3\u03c3\u03b5 \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u00ab\u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2\u00bb \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae\u03c2 <strong>ANKR<\/strong>, \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03b6\u03b1\u03bd \u03c4\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 DNA \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf KLEFS1 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03bc\u03b9\u03b1 <strong>\u03b7\u03c0\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03bf\u03c5 \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5 Kleefstra<\/strong> \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03cc\u03c4\u03b1\u03bd \u03bc\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03b5\u03c0\u03b7\u03c1\u03ad\u03b1\u03b6\u03b5 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac <strong>\u03bc\u03cc\u03bd\u03bf \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u201cwriter\u201d \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae\u03c2 SET<\/strong>, \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b4\u03b5\u03bd \u03ad\u03b2\u03bb\u03b5\u03c0\u03b1\u03bd \u03bf\u03cd\u03c4\u03b5 \u03c4\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 KLEFS1 \u03bf\u03cd\u03c4\u03b5 \u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1, \u03b3\u03b9\u03b1\u03c4\u03af \u03bc\u03b1\u03c2 \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c0\u03bb\u03bf\u03c5\u03c3\u03c4\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b9\u03b4\u03ad\u03b1 \u03cc\u03c4\u03b9:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u00ab\u03bf\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c3\u03c4\u03bf EHMT1 \u03b9\u03c3\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b5\u03af \u03bc\u03b5 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf Kleefstra\u00bb.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03cd\u03bd\u03b8\u03b5\u03c4\u03b7.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c4\u03bf \u00ab\u03b1\u03c0\u03bf\u03c4\u03cd\u03c0\u03c9\u03bc\u03b1 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2\u00bb \u03c4\u03bf\u03c5 Kleefstra;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0388\u03bd\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03ae\u03c4\u03b1\u03bd \u03b7 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b1\u03c6\u03ae\u03bd\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2. \u0391\u03c5\u03c4\u03cc \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 <strong>DNA methylation episignature<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03c0\u03bf\u03c1\u03bf\u03cd\u03bc\u03b5 \u03bd\u03b1 \u03c4\u03bf \u03c3\u03ba\u03b5\u03c6\u03c4\u03bf\u03cd\u03bc\u03b5 \u03c3\u03b1\u03bd \u03ad\u03bd\u03b1 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u00ab\u03b1\u03c0\u03bf\u03c4\u03cd\u03c0\u03c9\u03bc\u03b1\u00bb \u03c0\u03bf\u03c5 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c4\u03bf\u03c5\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03b1\u03bd \u03bc\u03b9\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03c9\u03bd Rots et al., \u03b1\u03c5\u03c4\u03cc \u03ae\u03c4\u03b1\u03bd \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b4\u03b5\u03bd \u03ae\u03c4\u03b1\u03bd \u03b5\u03be\u03b1\u03c1\u03c7\u03ae\u03c2 \u03c3\u03b1\u03c6\u03ae\u03c2. \u039f\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c3\u03c4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u00ab\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c3\u03c4\u03bf DNA;\u00bb, \u03b1\u03bb\u03bb\u03ac \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b7\u03c3\u03b1\u03bd \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03c3\u03bf\u03c5\u03bd <strong>\u03b1\u03bd \u03b7 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03b1\u03c6\u03ae\u03bd\u03b5\u03b9 \u03c4\u03bf \u03b1\u03bd\u03b1\u03bc\u03b5\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03cd\u03c0\u03c9\u03bc\u03b1<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03b7 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03ba\u03ac\u03c4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc: \u03b7 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd episignature \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ce\u03bd \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c5\u03c0\u03cc\u03c8\u03b7 \u03bf \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b7\u03c0\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b9\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c0\u03bf\u03c5 \u03be\u03b5\u03c7\u03ce\u03c1\u03b9\u03c3\u03b5 \u03ae\u03c4\u03b1\u03bd \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 <strong>N-terminal truncating variants<\/strong>, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c0\u03c1\u03cc\u03c9\u03c1\u03bf \u03c4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03c4\u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03b7\u03c0\u03b9\u03cc\u03c4\u03b5\u03c1\u03bf \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03cc \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf<\/strong> \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 KLEFS1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c0\u03cc \u03c4\u03b7\u03bd \u03ac\u03bb\u03bb\u03b7 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac, \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 EHMT1, \u03b7 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ae\u03c4\u03b1\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ac \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03c9\u03c2 Kleefstra. \u03a3\u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c5\u03c4\u03ae, <strong>94%<\/strong> \u03b5\u03af\u03c7\u03b1\u03bd \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c0\u03b7\u03c1\u03af\u03b1 \u03ae \u03bc\u03b1\u03b8\u03b7\u03c3\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 <strong>98%<\/strong> \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7. \u0391\u03c0\u03cc \u03c4\u03b1 12 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c5\u03c0\u03ae\u03c1\u03c7\u03b1\u03bd \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b1 \u03b1\u03c1\u03b9\u03b8\u03bc\u03b7\u03c4\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 IQ, \u03bf \u03bc\u03ad\u03c3\u03bf\u03c2 \u03cc\u03c1\u03bf\u03c2 \u03ae\u03c4\u03b1\u03bd 54.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03af \u03b1\u03c5\u03c4\u03bf\u03af \u03cc\u03bc\u03c9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03c9\u03bd\u00b7 <strong>\u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c8\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03bf\u03cd<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u03a4\u03bf Kleefstra \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b7\u03b8\u03b5\u03af<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0388\u03bd\u03b1 \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03bc\u03b5 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ae\u03c4\u03b1\u03bd \u03b7 \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7 <strong>\u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ce\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd KLEFS1<\/strong>, \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03bc\u03b9\u03b1 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03bf\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03b5\u03af\u03c7\u03b5 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b7\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03b3\u03bf\u03bd\u03ad\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf KLEFS1 \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5 \u03bd\u03ad\u03b5\u03c2, de novo \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2. \u0397 \u03bd\u03ad\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03cc\u03bc\u03c9\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03cd\u03bd\u03b8\u03b5\u03c4\u03b7: \u03ad\u03bd\u03b1\u03c2 \u03b3\u03bf\u03bd\u03ad\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03bf \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 <strong>\u03c0\u03bf\u03bb\u03cd \u03b7\u03c0\u03b9\u03cc\u03c4\u03b5\u03c1\u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf<\/strong>, \u03c3\u03b5 \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03ce\u03c3\u03c4\u03b5 \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03b5\u03af\u03c7\u03b5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03c5\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03b9\u03c3\u03c4\u03b5\u03af.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u038c\u03c4\u03b1\u03bd \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c0\u03b1\u03b9\u03b4\u03af \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c4\u03bf\u03c5 EHMT1 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b3\u03bf\u03bd\u03ad\u03b1, \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03bf \u03b3\u03bf\u03bd\u03ad\u03b1\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03ba\u03b1\u03bb\u03ac <strong>\u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b5\u03af \u03b7 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c9\u03c2 \u03b1\u03b2\u03bb\u03b1\u03b2\u03ae\u03c2<\/strong>. \u039f\u03b9 \u03c3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2 \u03c4\u03bf\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03bf\u03cd\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03ad\u03c9\u03bd, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u039d\u03ad\u03b1 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c8\u03c5\u03c7\u03b9\u03ba\u03ae \u03c5\u03b3\u03b5\u03af\u03b1<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b5\u03c0\u03ad\u03c4\u03c1\u03b5\u03c8\u03b5 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03bd\u03b1 \u03b4\u03bf\u03c5\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03c5 \u03af\u03c3\u03c9\u03c2 \u03b5\u03af\u03c7\u03b1\u03bd \u03c5\u03c0\u03bf\u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03b8\u03b5\u03af \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 5 \u03b5\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bd\u03c9 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c5\u03c0\u03ae\u03c1\u03c7\u03b1\u03bd \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1, \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c8\u03c5\u03c7\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ce\u03bd \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03c9\u03bd. \u039f\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c0\u03af\u03c3\u03c4\u03c9\u03c3\u03b1\u03bd \u03cc\u03c4\u03b9 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b5\u03c2 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 <strong>\u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c6\u03b7\u03b2\u03b5\u03af\u03b1 \u03ae \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b7 \u03b6\u03c9\u03ae<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b9\u03b4\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03bf\u03bd\u03c4\u03b1\u03bd, \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03ac\u03bb\u03bb\u03c9\u03bd, \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03b1\u03c5\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03c6\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2, \u03ac\u03b3\u03c7\u03bf\u03c2, \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac, \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 <strong>\u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03ae\u03b4\u03b7 \u03ba\u03b1\u03c4\u03b1\u03ba\u03c4\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03b4\u03b5\u03be\u03b9\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd \u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c7\u03ce\u03c1\u03b7\u03c3\u03b7<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03cc\u03bb\u03b5\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b8\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf \u03bc\u03b5 Kleefstra. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ac \u03bc\u03b7\u03bd\u03cd\u03bc\u03b1\u03c4\u03b1 \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03b7 <strong>\u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bb\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03af\u03c3\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u2019 \u03cc\u03c3\u03bf \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03c3\u03b1\u03bc\u03b5<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b5\u03c0\u03ad\u03c4\u03c1\u03b5\u03c8\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03b9\u03bf \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 <strong>\u03b4\u03c5\u03c3\u03ba\u03bf\u03b9\u03bb\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong> \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf 47% \u03c4\u03b7\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1\u03c2, \u03bf\u03b9 <strong>\u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b5\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2<\/strong> \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf 46% \u03ba\u03b1\u03b9 \u03bf\u03b9 <strong>\u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03cd\u03c0\u03bd\u03bf\u03c5\u2013\u03b5\u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03c3\u03b7\u03c2<\/strong> \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf 46%. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 \u03ae \u03c5\u03c0\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03bc\u03ce\u03bd \u03b5\u03af\u03c7\u03b5 \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf 29% \u03c4\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03bc\u03b5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03c5\u03c4\u03ac \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1. \u0394\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c0\u03c1\u03cc\u03b2\u03bb\u03b5\u03c8\u03b7 \u03b3\u03b9\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03c0\u03b1\u03b9\u03b4\u03af, \u03bf\u03cd\u03c4\u03b5 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b5\u03c4\u03b1\u03c3\u03c4\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc. \u0394\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03bc\u03c9\u03c2 \u03c0\u03bf\u03b9\u03b1 \u03b6\u03b7\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03bf\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03af \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03bc\u03b5 KLEFS1.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u03a0\u03cc\u03c3\u03bf \u03c3\u03c5\u03c7\u03bd\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0388\u03bd\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b7 \u03bd\u03ad\u03b1 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 KLEFS1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c4\u03bf\u03c5\u03c2, \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c5\u03c0\u03bf\u03bb\u03cc\u03b3\u03b9\u03c3\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03b1\u03bd\u03ac 36.000.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b1 \u03ba\u03b1\u03c4\u03b1\u03b3\u03b5\u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03c9\u03bd \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7. \u0395\u03af\u03bd\u03b1\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03cc \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b9\u03b4\u03ad\u03b1 \u03cc\u03c4\u03b9 \u03c4\u03bf KLEFS1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b1\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 <strong>\u03c5\u03c0\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03bc\u03ad\u03bd\u03bf<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03b7\u03c0\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2. \u0397 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 1:36.000 \u03c5\u03b9\u03bf\u03b8\u03b5\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf.<\/p>\n\n\n\n<div class=\"wp-block-group study-meaning\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">\u03a4\u03b9 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b1\u03c5\u03c4\u03ae \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u038a\u03c3\u03c9\u03c2 \u03c4\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra <strong>\u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03bc\u03af\u03b1 \u03b5\u03bd\u03b9\u03b1\u03af\u03b1, \u03c0\u03c1\u03bf\u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b9\u03c4\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c8\u03b5\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03c0\u03cc\u03c4\u03b5 \u03b8\u03b1 \u03c0\u03b5\u03c1\u03c0\u03b1\u03c4\u03ae\u03c3\u03b5\u03b9 \u03ae \u03b8\u03b1 \u03bc\u03b9\u03bb\u03ae\u03c3\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03c0\u03b1\u03b9\u03b4\u03af, \u03c0\u03cc\u03c3\u03bf \u03b8\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03b5\u03b9 \u03c4\u03b7 \u03b3\u03bb\u03ce\u03c3\u03c3\u03b1 \u03c4\u03bf\u03c5, \u03c0\u03bf\u03b9\u03bf \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5, \u03b1\u03bd \u03b8\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03c3\u03b5\u03b9 \u03b5\u03c0\u03b9\u03bb\u03b7\u03c8\u03af\u03b1, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03b9\u03ba\u03ad\u03c2 \u03ae \u03c8\u03c5\u03c7\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 \u03ae \u03c0\u03bf\u03b9\u03bf\u03c2 \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03b2\u03b1\u03b8\u03bc\u03cc\u03c2 \u03b1\u03bd\u03b5\u03be\u03b1\u03c1\u03c4\u03b7\u03c3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b7 \u03b6\u03c9\u03ae.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd Rots et al. \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd <strong>\u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af<\/strong> \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039a\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc \u03af\u03c3\u03c9\u03c2 \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03ad\u03bd\u03b1 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03b1\u03c5\u03c4\u03bf\u03cd \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03b5\u03b4\u03ce \u03ba\u03b1\u03b9 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1: \u03b4\u03cd\u03bf \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03bc\u03b5 KLEFS1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03bf\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03c4\u03c5\u03c0\u03c9\u03c3\u03b9\u03b1\u03ba\u03ac \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03b4\u03cc\u03bd 20 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c4\u03bf\u03c5 EHMT1<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf 2006 \u03b7 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 <strong>EHMT1<\/strong> \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03c9\u03c2 \u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03b9\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03c9\u03c2 Kleefstra \u03c4\u03cd\u03c0\u03bf\u03c5 1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c7\u03b5\u03b4\u03cc\u03bd \u03b4\u03cd\u03bf \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b5\u03c2 \u03b1\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1, \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03c9\u03bd Rots \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c4\u03ce\u03bd \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c0\u03cc\u03c3\u03bf \u03c0\u03bf\u03bb\u03cd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03be\u03b5\u03bb\u03b9\u03c7\u03b8\u03b5\u03af \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03ae \u03bc\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0394\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03c0\u03bb\u03ad\u03bf\u03bd \u03bd\u03b1 \u03c1\u03c9\u03c4\u03ac\u03bc\u03b5:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u00ab\u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c3\u03c4\u03bf EHMT1;\u00bb<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ac \u03bd\u03b1 \u03b8\u03ad\u03c4\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03cd \u03c0\u03b9\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c1\u03c9\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03bf\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae; \u03a3\u03b5 \u03c0\u03bf\u03b9\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2; \u03a0\u03bf\u03b9\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9; \u03a0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2; \u0395\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd ANKR \u03ae \u03c4\u03b7 SET \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae; \u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c4\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03cd\u03c0\u03c9\u03bc\u03b1; \u039a\u03b1\u03b9 \u03c0\u03ce\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03b2\u03b1\u03b8\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c4\u03cc\u03c3\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03ba\u03c1\u03b9\u03b2\u03ad\u03c3\u03c4\u03b5\u03c1\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03bc\u03ad\u03bb\u03bb\u03bf\u03bd \u03c4\u03b7\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0393\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2, \u03cc\u03bc\u03c9\u03c2, \u03af\u03c3\u03c9\u03c2 \u03c4\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03b9\u03c0\u03c9\u03b8\u03b5\u03af \u03c0\u03bf\u03bb\u03cd \u03c0\u03b9\u03bf \u03b1\u03c0\u03bb\u03ac:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra \u03ad\u03c7\u03b5\u03b9 \u03c0\u03bf\u03bb\u03cd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03bf\u03b9\u03ba\u03b9\u03bb\u03bf\u03bc\u03bf\u03c1\u03c6\u03af\u03b1 \u03b1\u03c0\u2019 \u03cc\u03c3\u03bf \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b1\u03bc\u03b5 \u03c3\u03c4\u03bf \u03c0\u03b1\u03c1\u03b5\u03bb\u03b8\u03cc\u03bd. \u0397 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03b2\u03bb\u03b5\u03c8\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03c0\u03b1\u03b9\u03b4\u03b9\u03bf\u03cd.<\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group study-source\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">\u03a0\u03b7\u03b3\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rots D, Bouman A, Yamada A, et al.<\/strong> <em>Comprehensive EHMT1 variants analysis broadens genotype-phenotype associations and molecular mechanisms in Kleefstra syndrome.<\/em> American Journal of Human Genetics. 2024;111(8):1605\u20131625. doi:<a href=\"https:\/\/www.cell.com\/action\/showPdf?pii=S0002-9297%2824%2900214-3\" data-type=\"link\" data-id=\"https:\/\/www.cell.com\/action\/showPdf?pii=S0002-9297%2824%2900214-3\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016\/j.ajhg.2024.06.008<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bouman A, et al.<\/strong> <em>International clinical evidence-based guideline for Kleefstra syndrome.<\/em> Genetics in Medicine. 2026. \u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b3\u03b5\u03bd\u03ad\u03c3\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c4\u03b7 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c0\u03bf\u03bb\u03b1\u03c3\u03bc\u03bf\u03cd \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 1:36.000.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u0393\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03ac \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1, \u03b7 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 Kleefstra \u03b2\u03b1\u03c3\u03b9\u03b6\u03cc\u03c4\u03b1\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac&#8230;<\/p>\n","protected":false},"author":1,"featured_media":2477,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[9],"tags":[145,151,147,36,148,144,137,37,130,152,153,143,146,124,132,138,149,139,140,150,123,97],"class_list":["post-2220","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-ankr","tag-de-novo-variants","tag-dna-methylation","tag-ehmt1","tag-episignature","tag-genetic-variants","tag-genotype-phenotype","tag-kleefstra-syndrome","tag-klefs1","tag-molecular-genetics","tag-precision-medicine","tag-rots-et-al","tag-set-domain","tag-124","tag-132","tag-138","tag-149","tag-139","tag-140","tag--kleefstra","tag-123"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin 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