{"id":707,"date":"2026-07-09T18:06:31","date_gmt":"2026-07-09T16:06:31","guid":{"rendered":"https:\/\/kleefstrasyndrome.com\/?p=707"},"modified":"2026-08-21T06:15:03","modified_gmt":"2026-08-21T04:15:03","slug":"study-links-ehmt2-new-kleefstra-like-disorder","status":"publish","type":"post","link":"https:\/\/kleefstrasyndrome.com\/el\/study-links-ehmt2-new-kleefstra-like-disorder\/","title":{"rendered":"\u039d\u03ad\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03b9 \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf EHMT2 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03cd\u03c0\u03bf\u03c5 Kleefstra"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u039c\u03b9\u03b1 \u03b4\u03b9\u03b5\u03b8\u03bd\u03ae\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c3\u03c5\u03bd\u03ad\u03b4\u03b5\u03c3\u03b5 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 <em>EHMT2<\/em> \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra. \u0397 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03bf <em>Nature Communications<\/em> \u03c4\u03b7\u03bd 1\u03b7 \u0399\u03bf\u03c5\u03bb\u03af\u03bf\u03c5 2026, \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03b5\u03c0\u03c4\u03ac \u03bd\u03ad\u03b5\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 (de novo), \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b3\u03bf\u03bd\u03b5\u03af\u03c2, \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1 \u00ab\u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03cc \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03ad\u03c2 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03bc\u03b5 \u03c4\u03bf EHMT2\u00bb. \u0393\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03c3\u03cd\u03b3\u03c7\u03c5\u03c3\u03b7\u03c2, \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ad\u03c3\u03c4\u03b5\u03c1\u03bf \u03bd\u03b1 \u03bc\u03b9\u03bb\u03ac\u03bc\u03b5 \u03b3\u03b9\u03b1 <strong>\u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c4\u03cd\u03c0\u03bf\u03c5 Kleefstra \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf EHMT2<\/strong>. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03bd\u03b5\u03bf\u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03cc\u03bc\u03b5\u03bd\u03b7, \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03ae \u03b1\u03bd\u03b1\u03b8\u03b5\u03ce\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 Kleefstra \u03c4\u03cd\u03c0\u03bf\u03c5 1, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf <em>EHMT1<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b3\u03b9\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03bc\u03b5 Kleefstra, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03b5\u03be\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03c4\u03bf <em>EHMT1<\/em>. \u0394\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af, \u03cc\u03bc\u03c9\u03c2, \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7. \u0394\u03b5\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf, \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03ae RNA \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2, \u03b4\u03b5\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c0\u03c1\u03bf\u03ad\u03ba\u03c5\u03c8\u03b5 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u0393\u03b9\u03b1\u03c4\u03af \u03c4\u03bf EHMT2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf EHMT1<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03b1\u03bd\u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03c4\u03b1 \u03b4\u03cd\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae. \u03a4\u03bf <em>EHMT1<\/em> \u03b4\u03af\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 GLP, \u03b5\u03bd\u03ce \u03c4\u03bf <em>EHMT2<\/em> \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 G9a. \u039f\u03b9 \u03b4\u03cd\u03bf \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c3\u03cd\u03bc\u03c0\u03bb\u03bf\u03ba\u03bf \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7: \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c0\u03bf\u03b9\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03ae \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03bd\u03b5\u03c1\u03b3\u03ac, \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 \u03c4\u03c9\u03bd \u00ab\u03b3\u03c1\u03b1\u03bc\u03bc\u03ac\u03c4\u03c9\u03bd\u00bb \u03c4\u03bf\u03c5 DNA.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03c3\u03cd\u03bc\u03c0\u03bb\u03bf\u03ba\u03bf GLP\/G9a \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c4\u03b5\u03af \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c7\u03b7\u03bc\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03ac\u03b4\u03b9\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03b9\u03c3\u03c4\u03cc\u03bd\u03b5\u03c2, \u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03b3\u03cd\u03c1\u03c9 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf DNA. \u039c\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 \u03c7\u03c1\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03c3\u03b2\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7. \u0397 \u03bd\u03ad\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac\u03c2 G9a\/EHMT2 \u03b1\u03c5\u03c4\u03bf\u03cd \u03c4\u03bf\u03c5 \u03ba\u03bf\u03b9\u03bd\u03bf\u03cd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03bf\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5 \u03b5\u03ba\u03b5\u03af\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 \u03c4\u03bf\u03c5 GLP\/EHMT1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra \u03c4\u03cd\u03c0\u03bf\u03c5 1, \u03bf \u03c3\u03c5\u03bd\u03b7\u03b8\u03ad\u03c3\u03c4\u03b5\u03c1\u03bf\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 <strong>\u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03ac\u03c6\u03bf\u03c5 \u03c4\u03bf\u03c5 EHMT1<\/strong>: \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b4\u03cd\u03bf \u03b1\u03bd\u03c4\u03af\u03b3\u03c1\u03b1\u03c6\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5, \u03b7 \u03bc\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03ae \u03b1\u03b4\u03c1\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03b7 \u03ac\u03bb\u03bb\u03b7 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7. \u039f\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03bf\u03c5 <em>EHMT2<\/em>. \u039f\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 G9a \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b5\u03bd\u03b1\u03bd \u03b4\u03bf\u03bc\u03b9\u03ba\u03ac \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ad\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd 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class=\"wp-block-paragraph\">\u0397 \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03c6\u03ae, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03ad\u03bd\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2 \u03bc\u03b9\u03b1\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae\u03c2. \u0394\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1, \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1, \u03b7 \u03bf\u03bc\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03ba\u03bf\u03b9\u03bd\u03ce\u03bd \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bf\u03b4\u03ce\u03bd, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03b4\u03cd\u03bf \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03af\u03b4\u03b9\u03b5\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b1\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03ba\u03b1\u03c4\u03ac \u03c0\u03cc\u03c3\u03bf \u03bf\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 G9a \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03c4\u03b7 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03bd\u03b6\u03c5\u03bc\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1. \u039a\u03b1\u03c4\u03ad\u03bb\u03b7\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03ae\u03c4\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03b5\u03c0\u03b1\u03c1\u03ba\u03b5\u03af\u03c2, \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03b3\u03bc\u03ad\u03bd\u03c9\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b9\u03c3\u03c4\u03cc\u03bd\u03b7 H3 \u03ae \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03b4\u03cc\u03c4\u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03bf\u03b9 \u03bc\u03b5\u03b8\u03c5\u03bb\u03bf\u03c4\u03c1\u03b1\u03bd\u03c3\u03c6\u03b5\u03c1\u03ac\u03c3\u03b5\u03c2. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b3\u03b9\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 \u03c1\u03bf\u03c5\u03c4\u03af\u03bd\u03b1\u03c2 \u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03cc\u03c7\u03bf \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03b5\u03c0\u03b9\u03ba\u03c5\u03c1\u03c9\u03b8\u03b5\u03af \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0388\u03bd\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7\u03c2 \u03c0\u03c1\u03bf\u03ae\u03bb\u03b8\u03b5 \u03b1\u03c0\u03cc \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c6\u03b5\u03c1\u03b1\u03bd \u03bc\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae <em>EHMT2<\/em> \u03c0\u03c1\u03bf\u03b5\u03c1\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae. \u03a4\u03b1 \u03b6\u03ce\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b1\u03bd \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2, \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03bf \u03ba\u03c1\u03b1\u03bd\u03af\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03ce\u03c0\u03bf\u03c5, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b7 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac. \u03a4\u03bf \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b6\u03c9\u03bd\u03c4\u03b1\u03bd\u03cc \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03b7 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b7 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b4\u03b5\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03b1\u03bd \u03bc\u03b9\u03b1 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b8\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ae \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2.<\/p>\n\n\n\n<div class=\"wp-block-group family-meaning\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0393\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03bc\u03b5 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03bf \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c4\u03bf\u03c5 <em>EHMT1<\/em> \u03ae \u03bc\u03b5 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae\u03c2 9q34.3 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf <em>EHMT1<\/em>, \u03b7 \u03bd\u03ad\u03b1 \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 Kleefstra \u03c4\u03cd\u03c0\u03bf\u03c5 1. \u0394\u03b5\u03bd \u03c3\u03c5\u03bd\u03b5\u03c0\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c3\u03c4\u03b9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2, \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7, \u03c3\u03c4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1, \u03c3\u03c4\u03bf \u03b5\u03ba\u03c0\u03b1\u03b9\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03ae \u03c3\u03c4\u03b9\u03c2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03b9\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2. \u0397 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03af\u03ba\u03b5\u03c5\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b8\u03b5\u03c1\u03ac\u03c0\u03bf\u03c5\u03c3\u03b5\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0393\u03b9\u03b1 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 Kleefstra \u03c7\u03c9\u03c1\u03af\u03c2 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03c3\u03c4\u03bf <em>EHMT1<\/em>, \u03c4\u03bf <em>EHMT2<\/em> \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c0\u03bb\u03ad\u03bf\u03bd \u03ad\u03bd\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b7\u03b8\u03b5\u03af 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\u0391\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf, \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9, \u03cc\u03c0\u03bf\u03c5 \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9, \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03ad\u03c9\u03bd. \u03a4\u03bf \u00ab\u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03cc \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03ad\u03c2\u00bb \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b5\u03b4\u03ce \u03cc\u03c4\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b3\u03bf\u03bd\u03ad\u03b1\u03c2 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H \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b5\u03c0\u03c4\u03ac de novo \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03b5\u03c2 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03c0\u03b9\u03bc\u03ad\u03c1\u03bf\u03c5\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7. \u0395\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03b5\u03af 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\u03c4\u03bf\u03bd \u03b5\u03ba\u03b4\u03cc\u03c4\u03b7 \u03c9\u03c2 \u03bc\u03b7 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03b5\u03c0\u03b9\u03bc\u03b5\u03bb\u03b7\u03bc\u03ad\u03bd\u03bf \u03c7\u03b5\u03b9\u03c1\u03cc\u03b3\u03c1\u03b1\u03c6\u03bf, \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b7 \u03b4\u03b9\u03b1\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03ae \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03ba\u03b1\u03b9\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac, \u03b7 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 G9a \u03bc\u03ad\u03c3\u03c9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ce\u03bd \u03c4\u03bf\u03c5 <em>EHMT2<\/em> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c3\u03c4\u03b5\u03bd\u03ac \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03bc\u03b5 \u03c4\u03bf Kleefstra. \u0395\u03af\u03bd\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03b1\u03c0\u03cc\u03b4\u03b5\u03b9\u03be\u03b7 \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03bf\u03bd\u03ce\u03bd \u03b8\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1. <\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group study-source\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">\u03a0\u03b7\u03b3\u03ad\u03c2<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-026-74987-w\" target=\"_blank\" rel=\"noopener noreferrer\">De novo EHMT2 variants cause an autosomal dominant EHMT2-related Kleefstra syndrome via loss of G9a methyltransferase activity | Nature Communications<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK47079\/\" target=\"_blank\" rel=\"noopener noreferrer\">Kleefstra Syndrome &#8211; GeneReviews\u00ae &#8211; NCBI Bookshelf<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b5\u03bd\u03c4\u03cc\u03c0\u03b9\u03c3\u03b1\u03bd \u03b5\u03c0\u03c4\u03ac \u03bd\u03ad\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03bf\u03c5 EHMT2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03c5 \u03ad\u03bc\u03bf\u03b9\u03b1\u03b6\u03b1\u03bd \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra \u03c4\u03cd\u03c0\u03bf\u03c5 1. \u0397 \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ae \u03c4\u03b7 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03bc\u03b5 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03bf\u03c5 EHMT1.<\/p>\n","protected":false},"author":1,"featured_media":2466,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[9],"tags":[36,50,52,51,37,53],"class_list":["post-707","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-ehmt1","tag-ehmt2","tag-epigenetics","tag-genetics","tag-kleefstra-syndrome","tag-rare-disease-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u039d\u03ad\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03b9 \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf EHMT2 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03cd\u03c0\u03bf\u03c5 Kleefstra - \u03a4\u03bf \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/kleefstrasyndrome.com\/el\/study-links-ehmt2-new-kleefstra-like-disorder\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u039d\u03ad\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03b9 \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf EHMT2 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03cd\u03c0\u03bf\u03c5 Kleefstra - \u03a4\u03bf \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Kleefstra\" \/>\n<meta property=\"og:description\" content=\"\u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b5\u03bd\u03c4\u03cc\u03c0\u03b9\u03c3\u03b1\u03bd \u03b5\u03c0\u03c4\u03ac 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